Bioinformatics Scientist - III (Senior)

Job Description

The Precision Genetics group within the Data and Genome Sciences Department is seeking a skilled Contractor to join our Computational Precision Immunology team. We are looking for a data scientist with extensive experience in multi-modal and multi-scale data analyses to contribute to our innovative research efforts.

Key Responsibilities:

• Data Ingestion: Query external databases to acquire relevant multi-omics datasets (e.g., PubMed, Gene Expression Omnibus, ArrayExpress, gnomAD, GTEx, Ensembl).

• RNA-seq Analysis: Perform quality control (QC) and analysis of bulk and single-cell RNA-seq data using state-of-the-art methods (e.g., FastQC, STAR, Limma, DESeq2, clusterProfiler, Seurat, scanpy, LeafCutter).

• Multi-Omics Analysis: Analyze diverse molecular data types including spatial transcriptomics (e.g., Slide-seq, MERFISH, squidpy) and proteomics (e.g., OLINK, mass spectrometry-based approaches).

• Data Integration: Integrate multi-omics datasets, including gene/protein expression, mRNA splicing, spatial transcriptomics, and genotype data.

• Documentation: Prepare detailed documentation of analysis methods and results in a timely manner.

Quals--

Required Qualifications:

• Ph.D. in Computational Biology or a related field.

• A proven track record of over 5 years in multi-omics analysis.

• Fundamental understanding of statistical methods and multi-omics data analysis and integration (e.g., RNA-Seq, single-cell RNA-Seq, genotype, spatial transcriptomics, OLINK).

• Proficiency in R, Python, and Bash, with the ability to establish best practices for reproducible data analyses.

• Experience with high-performance computing (HPC) systems and AWS Cloud Computing (e.g., IAM, S3 buckets).

• A collaborative and self-motivated individual with a strong work ethic, capable of managing multiple objectives in a dynamic environment and adapting to changing priorities.

• Excellent written and verbal communication skills.

Preferred Qualifications:

• Experience in processing and analyzing real-world data.

• Familiarity with spatial transcriptomics analysis.

• Knowledge of statistical and population genetics principles.

Note:

• Onsite role at Cambridge, MA.

• Do not submit candidates who are looking for remote.

• Do not submit candidates with just BS/MS.

Key Skills:

• Required expertise with multi-omics data analysis and integration (e.g., RNA-Seq, single-cell RNA-Seq.

• Transcriptomics analysis.

• Proficiency in R and Bash.

• High-performance computing (HPC) systems and AWS Cloud Computing (e.g., IAM, S3 buckets).