Job Description
Oncologist / Principal Investigator - Clinical Research leadership
Location: Los Angeles, CA
Employment Type: Full-Time, On-Site
Overview
We are representing an exceptional research-focused oncology organization seeking a Principal Investigator (PI) to oversee a highly experienced clinical team and drive breakthrough studies with biotech sponsors.
This is a full-time, research-only role, offering the opportunity to guide cutting-edge oncology trials in a fast-growing, data-driven clinical environment.
The position is ideal for an oncologist who wants to transition from purely clinical practice into a leadership role at the intersection of science, medicine, and industry, helping advance next-generation cancer therapies.
Key Responsibilities
- Serve as the Principal Investigator for oncology trials across multiple modalities and sponsors.
- Provide medical oversight, ensure patient safety, and maintain protocol compliance and data integrity.
- Supervise and mentor sub-investigators, nurse practitioners, and clinical operations staff.
- Collaborate closely with sponsors, CROs, and internal study teams to drive enrollment and site performance.
- Support scientific and operational strategy, SOP refinement, and future site development.
- Participate in investigator meetings, safety reviews, and regulatory inspections.
Ideal Candidate
- MD or DO with board certification or eligibility in Hematology/Oncology (or related discipline).
- Licensed or license-eligible to practice medicine in California.
- 1–5+ years post-fellowship experience (early-career attendings encouraged to apply).
- Demonstrated clinical excellence and the ability to manage oncology patients in a research setting.
- Prior Sub-I or PI experience preferred but not required — full GCP training and mentorship provided.
- Strong communication skills, collaborative mindset, and enthusiasm for research and innovation.
- Must be committed to a full-time, on-site position.
Why This Opportunity
- Exceptional Organization — culture of scientific rigor, integrity, and collaboration.
- Exposure to Cutting-Edge Oncology Programs — work on next-generation therapeutic approaches.
- Leadership Trajectory — opportunity to expand into multi-site or network-level leadership.
- Competitive Compensation — highly attractive package with relocation and performance incentives.
This search is being managed exclusively by Plexus Partners.
Interested candidates can submit a CV or express interest in confidence to: