Job Description
Job DescriptionSalary: $152,000 - $183,000
TheSenior Scientist, Research position is a key member of the Genomics Platform team and will be involved in bioinformatics analyses of genomics and multi-omics datasets to support our drug discovery and therapeutic development at Visterra. Reporting to the Executive Director of Research, this person will play a lead role in developing and applying advanced computational approaches to analyze and interpret genetics, genomics and multi-omics datasets to support our drug development decisions. We are seeking an experienced bioinformatician to develop and adapt data-driven approaches to analyze single cell multi-omics, spatial transcriptomics, genetics and other high-content datasets to aid target identification, disease characterization and mechanism-of-action studies to derive biological insights supporting drug candidate discovery and development.
Responsibilities
- Develop and implement advanced machine learning and computational strategies, including deep learning, graph-based methods, and probabilistic modeling, to extract insights genomics datasets, including single-cell, spatial and genetic modalities.
- Collaborate with internal and external scientists and clinicians to drive insights from multi-omic data, supporting novel therapeutic development.
- Develop new bioinformatics strategies efforts to address key target identification questions on underlying biological mechanisms of disease.
- Leverage and extend best practices from genomics, statistics, and data science to process and analyze internal and public multi-omics data and derive biological insights that will impact program strategy.
- Manage existing high-dimensional data resources and ingest new public and internal datasets for use by team members.
- Clearly communicate complex data findings to colleagues and senior management.
- Engage in research discussions, proactively suggesting innovative solutions to impact discovery and clinical programs.
- Stay current with advancements in computational biology by reviewing literature, evaluating new technologies, and implementing relevant methodologies.
- Present research findings at conferences and publish in scientific journals.
- Participate in research team meetings, and proactively suggest new ways to impact programs from discovery through the clinic.
- Maintain expertise in the field by staying current with relevant literature, proactively evaluate new technologies, and implement in-house where appropriate.
Requirements
- PhD. in Computational Biology, Bioinformatics, Computer Science, or a related field with 4+ years of experience, or a M.S. with 10 years of relevant experience.
- Expertise in single-cell genomics (scRNA-seq), spatial transcriptomics, genetics or other large-scale multi-dimensional genomics analyses.
- Deep experience implementing workflows to process high-throughput -omics data and performing downstream analyses that generate biological insights.
- Proven track record of evaluating and using public biology databases, with an understanding of how to utilize large datasets to drive discovery and development
- Deep understanding in computational single cell toolsets such as Seurat, Scanpy, and other relevant methods.
- Strong programming skills in Python and/or R for bioinformatics applications.
- Familiarity with cloud computing services, such as AWS, is
- Excellent collaboration and interpersonal skills for multi-disciplinary teamwork.
- Strong problem-solving abilities, analytical thinking, and intellectual curiosity.
- Exceptional written and verbal communication skills, with the ability to present complex ideas clearly to diverse audiences.
- Passion for developing computational technologies for biological research and translating findings into therapeutic applications in precision medicine and translational research.
Management responsibilities: This position may include supervisory responsibilities.
Travel: Possible travel to local and national conferences
Company
Visterra is a clinical stage biotechnology company committed to developing innovative antibody-based therapies for the treatment of patients with kidney, immune-mediated and other hard-to-treat diseases. Our proprietary technology platform enables the design and engineering of precision antibody-based product candidates that specifically bind to, and modulate, key disease targets. Applying this technology to disease targets that are not adequately addressed by traditional therapeutic approaches, we are developing a robust pipeline of novel therapies for patients with unmet needs. Visterras pipeline has multiple clinical-stage assets and one approved therapeutic, sibeprenlimab.
As a member of the Otsuka family of companies, we are uniquely positioned as a small, dynamic, nimble and innovative organization where individuals and teams are empowered to make big impacts while benefiting from the support, strength, stability and long-term perspective of a 100-year-old global company. Visterra has approximately 105 employees and is located in Waltham, Massachusetts.