Job Description
Job Description
What you’ll do:
- Design and execute pharmacology studies with small molecule therapeutics in murine disease models of oncology. Activities include cell culture, cell inoculation, dosing, monitoring of disease progression, sample collection and maintaining study documentation.
- Conducting studies to evaluate targets, combination strategies, biomarkers and establish efficacy, PK/PD relationships.
- Contribute to the internal development of cancer xenograft models.
- Play a key role in evaluating mechanistic hypotheses for drug responses using samples generated from studies, utilizing diverse molecular biology techniques to assess gene modulation and interrogate pathways of interest.
- Maintain rigorous records in ELN; perform basic QC and data summaries (Excel, GraphPad Prism); present findings at team meetings.
- Operate and maintain equipment (isoflurane anesthesia, biosafety cabinet, balances, centrifuges); manage consumables
- Author preclinical study reports.
- Ensuring current IACUC protocols are maintained.
- Participate in weekend/holiday dosing and monitoring on a rotating schedule.
Requirements:
- BS/BA in Biology, Pharmacology, or related At least 1-2+ years hands-on experience
- Experience with xenografts and syngeneic models, in vivo assays for pharmacokinetic evaluations and cell culture is a plus.
- Efficient time management and the ability to work on several projects simultaneously.
- Strong interpersonal skills and effective communication with multiple research teams.
- Has the ability to work independently and adapt to shifting priorities and timelines.
- Attention to detail and enthusiasm for integrating basic science learnings with drug discovery efforts.
- Experience with data capturing and analysis software (i.e. electronic notebook, StudyLog, PRISM, Excel).
- Expertise in in vitro/ex vivo assays including qPCR, MSD/ELISA, IHC, FACS is a plus.
- Weekend and holiday work may be required.